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Review

End-of-life prognostic indicators in patients with COPD: Part 1

    Published Online:1 Nov 2016https://doi.org/10.12968/ijpn.2016.22.10.508

    Abstract

    In the UK, chronic respiratory diseases cause 13% of adult disability. The major chronic respiratory disease is chronic obstructive pulmonary disease (COPD), a condition involving chronic airway inflammation that causes airflow obstruction and destruction of lung tissue. This leads to a progressive loss of respiratory membrane, which accounts for the clinical manifestation of COPD, which is difficulty maintaining sufficient gas exchange to meet metabolic demands. The primary cause is smoking, with the vast majority of COPD patients having a past or present history of smoking. However exposure to industrial pollutants is also a contributing factor, as is a rare genetic predisposition to developing COPD.

    References

    • Aanerud M, Saure EW, Benet M et al. (2014) Serial measurements of arterial oxygen tension are associated with mortality in COPD. COPD 12(3): 287–94 Medline, Google Scholar
    • Addington-Hall JM, 1998. Reaching out: specialist palliative care for adults with non-malignant diseases. London: National Council for Hospice and Specialist Palliative Care Services Google Scholar
    • Andersson FL, Svensson K and Gerhardosson de Verdier M (2006) Hospital use for COPD patients during the last few years of life. Respir Med 100(8): 1436–41 Crossref, Medline, Google Scholar
    • Ahmadi S, Bornefalk-Hermansson A, Franklin KA et al. (2014) Hypo-and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: a population-based prospective study. Respir Res, 15(1): 1 Crossref, Medline, Google Scholar
    • Boland J, Martin J, Wells AU, Ross JR (2013) Palliative care for people with non-malignant lung disease: summary of current evidence and future direction. Palliat Med 27(9): 811–6 Crossref, Medline, Google Scholar
    • Buxton KL, Stone AR, Buckingham RJ, Pursey NA, Roberts CM (2010) Current and planned palliative care service provision for chronic obstructive pulmonary disease patients in 239 UK hospital units: comparison with the gold standards framework. Palliat Med 24(5): 480–5 Crossref, Medline, Google Scholar
    • Cardoso F, Tufanin AT, Colucci M et al. (2007) Replacement of the 6–min walk test with maximal oxygen consumption in the BODE index applied to patients with COPD. Chest 132(2): 477–82 Crossref, Medline, Google Scholar
    • Casanova C, Cote C, Marin JM et al. (2008) Distance and oxygen desaturation during the 6–min walk test as predictors of long-term mortality in patients with COPD. Chest 134(4): 746–52 Crossref, Medline, Google Scholar
    • Casanova C, Cote C, Marin JM et al. (2007) The 6-min walking distance: long-term follow up in patients with COPD. Eur Respir J 29(3): 535–40 Crossref, Medline, Google Scholar
    • Celli NBR, Cote CG, Marin JM et al. (2004) The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 350(10): 1005–12 Crossref, Medline, Google Scholar
    • Celli BR, Locantore N, Yates J et al. (2012) Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 185(10): 1065–72 Crossref, Medline, Google Scholar
    • Chambellan A, Chailleux E and Similowski T (2005) Prognostic value of the Hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 128(3): 1201–8 Crossref, Medline, Google Scholar
    • Chang CL, Robinson SC, Mills GD et al. (2011) Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD. Thorax 66(9): 764–8 Crossref, Medline, Google Scholar
    • Chen H, Wang Y, Bai C, Wang X (2012) Alterations of plasma inflammatory biomarkers in the healthy and chronic obstructive pulmonary disease patients with or without acute exacerbation. Journal of Proteomics 75(10): 2835–43 Crossref, Medline, Google Scholar
    • Cote CG, Pinto-Plata V, Kasprsyk (2007) The 6-min walking distance, peak oxygen uptake, and mortality in COPD. Chest 123(6): 1778–85 Crossref, Google Scholar
    • Cote CG, Pinto-Plata V, Marin JM et al. (2008) The modified BODE index: validation with mortality in COPD. Eur Respir J 32(5): 1269–74 Crossref, Medline, Google Scholar
    • Dahl M and Nordestgaard BG (2009) Markers of early disease and prognosis in COPD. Int J Chron Obstruct Pulmon Dis 4: 157–67 Medline, Google Scholar
    • Edmonds P, Karlsen S, Khan S, Addington-Hall JA (2001) A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliat Med 15: 287–95 Crossref, Medline, Google Scholar
    • Elkington H, White P, Addington-Hall J, Higgs R, Edmonds P (2005) The healthcare needs of chronic obstructive pulmonary disease patients in the last year of life. Palliat Med 19(6): 485–91 Crossref, Medline, Google Scholar
    • Elkington H, White P, Addington-Hall J, Higgs R, Pettinari C (2004) The last year of life of COPD: a qualitative study of symptoms and services. Respir Med 98: 439–45 Crossref, Medline, Google Scholar
    • Glope R, Castro-Anon O, Peres-de-Lamo LA et al. (2014) Prognostic significance of six-minute walk test in non-group 1 pulmonary hypertension. Heart and Lung 43: 72–6 Crossref, Medline, Google Scholar
    • Glope R, Peres-de-Lamo LA, Mendes-Marote L et al. (2013) Prognostic value of walk distance, work, oxygen desaturation, and dyspnoea during 6-minute walk test in COPD patients. Respiratory Care 58(8): 1329–34 Crossref, Medline, Google Scholar
    • Gore JM, Brophy CJ, Greenstone MA (2000) How well do we care for patients with end stage chronic obstructive pulmonary disease (COPD)? A comparison of palliative care and quality of life in COPD and lung cancer. Thorax 55: 1000–6 Crossref, Medline, Google Scholar
    • Grolimund E, Kuts A, Marlowe RJ et al. (2014) Long-term Prognosis in COPD Exacerbation: Role of Biomarkers, Clinical Variables and Exacerbation Type. COPD 12(3): 295–305 Medline, Google Scholar
    • HajGanbari B, Garland SJ, Road JD et al. (2013) Pain and physical performance in people with COPD. Respir Med 2013 107(11): 1692–9 Crossref, Medline, Google Scholar
    • Higashimoto Y, Iwata T, Okada M et al. (2009) Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir Med 103(8): 1231–8 Crossref, Medline, Google Scholar
    • Hoiseth AD, Neukamm A, Hagve TA (2014) The clinical value of serial measurement of high-sensitivity cardiac troponin T in acute exacerbations of chronic obstructive pulmonary disease. Open Heart 1(1): 1–7 Crossref, Google Scholar
    • Huerta A, Crisafulli E, Menendes R et al. (2013) Penumonic and nonpneumonic exacerbations of COPD inflammatory response and clinical characteristics. Chest 144(4): 1134–41 Crossref, Medline, Google Scholar
    • Justo D, Lachmi S, Saara N et al. (2009) C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia. Eur J Intern Med 20(5): 518–21 Crossref, Medline, Google Scholar
    • Kinnuen T, Saynajakangas O and Keistinen T (2007) The COPD-induced hospitalisation burden from first admission to death. Respirat Med 101(2): 294–9 Crossref, Medline, Google Scholar
    • Ko FWS, Tam W, Tung A et al. (2011) A longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD. Respirat Med 105(2): 266–73 Crossref, Medline, Google Scholar
    • Liu SF, Wang CC, Chin CH et al. (2011) High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD. Arch Bronconeumol 47(9): 427–32 Crossref, Medline, Google Scholar
    • Lumb AB (2010) Nunn's applied respiratory physiology. (7th edn). Edinburgh: Churchill Livingstone Google Scholar
    • Marin JM, Cote CG, Dias O et al. (2011) Prognostic assessment in COPD: health related quality of life and the BODE index. Respirat Med 105(6): 916–21 Crossref, Medline, Google Scholar
    • Martines FJ, Han MK, Andrei A et al. (2008) Longitudinal change in the BODE index predicts mortality in severe emphysema. Am J Respir Crit Care Med 178(5): 491–9 Crossref, Medline, Google Scholar
    • Oga T, Nishimura K, Tsukino M et al. (2003) Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med 167(4): 544–9 Crossref, Medline, Google Scholar
    • Oga T, Nishimura K, Tsukino M et al. (2005) Exercise capacity deterioration in patients with COPD. Chest 128(1): 62–9 Crossref, Medline, Google Scholar
    • Oga T, Tsukino M, Hajiro T et al. (2011) Predictive properties of different multidimensional staging systems in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 6: 521–6 Crossref, Medline, Google Scholar
    • Pinto-Plata VM, Cote C, Cabral H et al. (2014) The 6-min walk distance: change over time and value as a predictor of survival in severe COPD. European Respiratory Journal 23(1): 28–33 Crossref, Google Scholar
    • Puhan MA, Garcia-Aymerich J, Frey M et al. (2009) Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index. Lancet 374: 704–11 Crossref, Medline, Google Scholar
    • Roberts MH, Mapel DW, Bruse S et al. (2013) Development of a modified BODE index as a mortality risk measure among older adults with and without. Am J Epidemiol 178(7): 1150–60 Crossref, Medline, Google Scholar
    • Similowski T, Agusti A, MacNee W et al. (2006) The potential impact of anaemia of chronic disease in COPD. European Respiratory Journal 27(2): 390–6 Crossref, Medline, Google Scholar
    • Silverberg DS, Mor R, Weu MT et al. (2014) Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron. BMC Pulm Med 14(1): 24 Crossref, Medline, Google Scholar
    • Soler-Cataluna JJ, Martines-Garcia MA, Sanches LS et al. (2009) Severe exacerbations and BODE index: Two independent risk factors for death in male COPD patients. Respiratory Medicine 103(5): 692–9 Crossref, Medline, Google Scholar
    • Spruit MA, Watkins ML, Edwards LD et al. (2010) Determinants of poor 6-min walking distance in patients with COPD: The ECLIPSE cohort. Respirat Med 104(6): 849–57 Crossref, Medline, Google Scholar
    • Suur-Telgen MC, Brusse-Keiser MGJ, VanderValk PDLPM et al. (2014) Stable-state midrange-proadrenomedullin levels is a strong predictor of mortality in patients with COPD. Chest 145(3): 534–41 Crossref, Google Scholar
    • Takigawa N, Tadaa A, Sodaa R et al. (2007) Distance and oxygen desaturation in 6-min walk test predict prognosis in COPD patients. Respiratory Medicine 101(3): 561–7 Crossref, Medline, Google Scholar
    • Veigi G, Scognamiglio A, Baldacci S et al. (2001) Epidemiology of Chronic Obstructive Pulmonary Disease (COPD). Respiration 68(1): 4–19 Crossref, Medline, Google Scholar
    • World Health Organisation (2006) Global strategy for the diagnosis, Management, and prevention of chronic obstructive pulmonary disease. Available from: http://tinyurl.com/jodyw48 (accessed 10 September 2016) Google Scholar
    • Youssef ARI, Hassan ASA, El-Ghamry R et al. (2013) Serum troponin-I as a prognostic marker in acute exacerbated chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc 62(4): 549–55 Crossref, Google Scholar

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