This website is intended for healthcare professionals

Abstract

The most common types of chronic inflammatory arthritis are rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. In order to assess the activity of these diseases and tailor therapy, several outcome measures have been developed. They include composite scores based on clinical findings, biochemical markers and patient questionnaires. This article discusses the most commonly used outcome measures and looks at their limitations in quantifying the complex clinical features of different types of inflammatory arthritis, focusing in particular on rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.

References

  • Anderson J, Caplan L, Yazdany J et al. (2012) Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice. Arthritis Care Res 64(5): 640–647. https://doi.org/https://doi.org/10.1002/acr.21649 CrossrefGoogle Scholar
  • Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 21(12): 2281–2285. MedlineGoogle Scholar
  • Coates LC, Tillett W, Chandler D et al.; BSR Clinical Affairs Committee & Standards, Audit and Guidelines Working Group and the BHPR (2013) The 2012 BSR and BHPR guideline for the treatment of psoriatic arthritis with biologics. Rheumatology 52(10): 1754–1757. https://doi.org/https://doi.org/10.1093/rheumatology/ket187 Crossref, MedlineGoogle Scholar
  • Davis JC Jr (2005) Ankylosing Spondylitis. Arthritis and allied conditions. Lippincott Williams & Wilkins, Philadelphia Google Scholar
  • Fransen J, van Riel PLCM (2005) The disease activity score and the EULAR response criteria. Clin Exp Rheumatol 23(5) Suppl 39: S93–S99. MedlineGoogle Scholar
  • Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12): 2286–2291. MedlineGoogle Scholar
  • Gladman DD, Cook RJ, Schentag C et al. (2004) The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of Canada. J Rheumatol 31(6): 1126–1131. MedlineGoogle Scholar
  • Gladman DD, Mease PJ, Healy P et al. (2007) Outcome measures in psoriatic arthritis. J Rheumatol 34(5): 1159–1166. MedlineGoogle Scholar
  • Hendrikx J, de Jonge MJ, Fransen J, Kievit W, van Riel PL (2016) Systematic review of patient-reported outcome measures (PROMs) for assessing disease activity in rheumatoid arthritis. RMD Open 2(2):e000202. https://doi.org/https://doi.org/10.1136/rmdopen-2015-000202 Crossref, MedlineGoogle Scholar
  • Heuft-Dorenbosch L, Spoorenberg A, van Tubergen A et al. (2003) Assessment of enthesitis in ankylosing spondylitis. Ann Rheum Dis 62(2): 127–132. https://doi.org/https://doi.org/10.1136/ard.62.2.127 Crossref, MedlineGoogle Scholar
  • Hughes E, van Onselen J (2001) Dermatology Nursing, A Practical Guide. Churchill Livingstone, Edinburgh Google Scholar
  • Mease PJ (2011) Measures of psoriatic arthritis: Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesit. Arthritis Care Res 63(S11) Suppl 11: S64–S85. https://doi.org/https://doi.org/10.1002/acr.20577 CrossrefGoogle Scholar
  • National Collaborating Centre for Chronic Conditions (2009) Rheumatoid arthritis: national clinical guideline for management and treatment in adults. www.nice.org.uk/guidance/cg79/evidence/full-guideline-pdf-242191261 (accessed 12 June 2017) Google Scholar
  • Orbai AM, Mease PJ, de Wit M et al. (2016) Report of the GRAPPA-OMERACT Psoriatic Arthritis Working Group from the GRAPPA 2015 Annual Meeting. J Rheumatol 43(5): 965–969. https://doi.org/https://doi.org/10.3899/jrheum.160116 Crossref, MedlineGoogle Scholar
  • Sandre MK, Rohekar S, Guenther L (2015) Psoriatic nail changes are associated with clinical outcomes in psoriatic arthritis. J Cutan Med Surg 19(4): 367–376. https://doi.org/https://doi.org/10.1177/1203475415573663 Crossref, MedlineGoogle Scholar
  • van der Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van der Linden S; Assessments in Ankylosing Spondylitis Working Group (1997) Preliminary core sets for endpoints in ankylosing spondylitis. J Rheumatol 24(11): 2225–2229. MedlineGoogle Scholar
  • van der Heijde D, Landewé R, Feldtkeller E (2008) Proposal of a linear definition of the Bath Ankylosing Spondylitis Metrology Index (BASMI) and comparison with the 2-step and 10-step definitions. Ann Rheum Dis 67(4): 489–493. https://doi.org/https://doi.org/10.1136/ard.2007.074724 Crossref, MedlineGoogle Scholar
  • van Gestel AM, Anderson JJ, van Riel PL et al.; American College of Rheumatology European League of Associations for Rheumatology (1999) ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. J Rheumatol 26(3): 705–711. MedlineGoogle Scholar

This website is intended for healthcare professionals