Heart failure and COVID-19: synergism of two inflammatory conditions?
Abstract
Heart failure as a comorbidity in the older population with COVID-19 poses an additional threat to those affected. Patients with both COVID-19 and heart failure share similar risk factors, which result in magnification of pathological outcomes. These include a common inflammatory pathology and related coagulopathy. Both illnesses pose a risk of arrhythmia. Polypharmacy further complicates safe drug administration and worsens the risk of medication-induced arrhythmia. Additionally, both conditions present challenges regarding attaining and maintaining an appropriate nutritional state. Exploration of the interplay between these factors demonstrates the gravity of the co-existence of these conditions and helps understand the difficulties faced when caring for this patient group. Although care provided to COVID-19 patients is primarily related to symptom presentation, based on the analysis conducted, there are some recommendations for practice in relation to evidence and guidelines when managing heart failure patients in primary care within the context of the COVID-19 pandemic.
References
- Hydroxychloroquine and QTc prolongation in patients with COVID-19: a systematic review and meta-analysis. Indian Pacing Electrophysiol J. 2020. https://doi.org/10.1016/j.ipej.2020.10.002 Crossref, Google Scholar
- Hospitalizations for heart failure during the COVID-19 pandemic: making sense of the known knowns, known unknowns, and unknown unknowns. Eur J Heart Failure. 2020; 22(1):1752–1754. https://doi.org/10.1002/ejhf.1955 Crossref, Medline, Google Scholar
- Atrioventricular and sinus node dysfunction in stable COVID-19 patients. SN Compr Clin Med. 2020a; Sep 4:1–4. https://doi.org/10.1007/s42399-020-00497-5 Google Scholar
- Arrhythmia in COVID-19. SN Compr Clin Med. 2020b; 2:1430–1435. https://doi.org/10.1007/s42399-020-00454-2 Crossref, Google Scholar
- Heart failure and COVID-19. Heart Failure Rev. 2020. https://doi.org/10.1007/s10741-020-10008-2 Crossref, Medline, Google Scholar
- COVID-19 therapies and their impact on QT interval prolongation: a multicentre retrospective study on 196 patients. IJC Heart Vasculature, 2020; 30: 100637. https://doi.org/10.1016/j.ijcha.2020.100637 Crossref, Medline, Google Scholar
- Vitamin D and COVID-19: it is time to act. Int J Clin Pract. 2020. https://doi.org/10.1111/ijcp.13748 Crossref, Medline, Google Scholar
- The impact of COVID-19 on heart failure hospitalization and management: report from a Heart Failure Unit in London during the peak of the pandemic. Eur J Heart Failure. 2020; 22(6):978–984. https://doi.org/10.1002/ejhf.1925 Crossref, Medline, Google Scholar
- Temporal trends in decompensated heart failure and outcomes during COVID-19: a multisite report from heart failure referral centres in London. Eur J Heart Failure. 2020. https://doi.org/10.1002/ejhf.1986 Crossref, Google Scholar
- Coronavirus disease (COVID-19–SARS-CoV-2) and nutrition: is infection in Italy suggesting a connection? Front Immunol. 2020; 11:944. https://doi.org/10.3389/fimmu.2020.00944 Crossref, Medline, Google Scholar
- Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020; 368. https://doi.org/10.1136/bmj.m1091 Google Scholar
- COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020; 135(23):2033–2040. https://doi.org/10.1182/blood.2020006000 Crossref, Medline, Google Scholar
- The case fatality rate in COVID-19 patients with cardiovascular disease: global health challenge and paradigm in the current pandemic. Curr Pharmacol Rep. 2020; Sep 15:1–10. https://doi.org/10.1007/s40495-020-00239-0 Medline, Google Scholar
- Silent atrial fibrillation: epidemiology, diagnosis, and clinical impact. Clin Cardiol. 2017; 40(6):413–418. https://doi.org/10.1002/clc.22667 Crossref, Medline, Google Scholar
- A comprehensive review of COVID-19 characteristics. Biolog Proc Online. 2020; 22:19. https://doi.org/10.1186/s12575-020-00128-2 Crossref, Medline, Google Scholar
- Organ-specific manifestations of COVID-19 infection. Clin Experiment Med. 2020. https://doi.org/10.1007/s10238-020-00648-x Crossref, Google Scholar
- COVID-19 associated atrial fibrillation: incidence, putative mechanisms and potential clinical implications. IJC Heart Vasculature. 2020. https://doi.org/10.1016/j.ijcha.2020.100631 Google Scholar
- COVID-19 and the heart: an update for clinicians. Clin Cardiol. 2020. https://doi.org/10.1002/clc.23406 Crossref, Medline, Google Scholar
- Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: crosstalk among calorie restriction, autophagy and immune response. Immunol Lett. 2020; 226:38–45. https://doi.org/10.1016/j.imlet.2020.07.001 Crossref, Medline, Google Scholar
- D-dimer level and long-term outcome in patients with end-stage heart failure secondary to idiopathic dilated cardiomyopathy. JGC. 2019; 16(8):621–629. https://doi.org/10.11909/j.issn.1671-5411.2019.08.005 Google Scholar
- Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients. 2020; 12(6):1562. https://doi.org/10.3390/nu12061562 Crossref, Google Scholar
- 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur J Cardiothorac Surg. 2016; 50(5):e1–e88. https://orbi.uliege.be/handle/2268/205593 Google Scholar
- Severe hypertension with renal thrombotic microangiopathy: what happened to the usual suspect? Kidney Int. 2017; 91(6):1271–1274. https://doi.org/10.1016/j.kint.2017.02.025 Crossref, Medline, Google Scholar
- Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020; 7(6):e438–e440. https://doi.org/10.1016/S2352-3026(20)30145-9 Crossref, Medline, Google Scholar
- Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020; 146(1):110–118. https://doi.org/10.1016/j.jaci.2020.04.006 Crossref, Medline, Google Scholar
- Coronavirus disease-19 and cardiovascular disease: a risk factor or a risk marker? Rev Med Virol. 2020. https://doi.org/10.1002/rmv.2172 Crossref, Google Scholar
- Factors associated with increased morbidity and mortality of obese and overweight COVID-19 patients. Biology. 2020. https://doi.org/10.3390/biology9090280 Google Scholar
- COVID-19 cytokine storm: the anger of inflammation. Cytokine. 2020; 133:155151. https://doi.org/10.1016/j.cyto.2020.155151 Crossref, Medline, Google Scholar
- SARS-CoV-2: a storm is raging. J Clin Invest. 2020; 130(5):2202–2205. https://doi.org/10.1172/JCI137647 Crossref, Medline, Google Scholar
- Impact of Vitamin D Deficiency on COVID-19-a prospective analysis from the CovILD Registry. Nutrients. 2020. https://doi.org/10.3390/nu12092775 Crossref, Medline, Google Scholar
- Sympathetic activation: A potential link between comorbidities and COVID-19. FEBS J. 2020. https://doi.org/10.1111/febs.15481 Crossref, Medline, Google Scholar
- Vitamin D deficiency and outcome of COVID-19 patients. Nutrients. 2020. https://doi.org/10.3390/nu12092757 Crossref, Google Scholar
- The COVID-19 cytokine storm: what we know so far. Front Immunol. 2020. https://doi.org/10.3389/fimmu.2020.01446 Crossref, Medline, Google Scholar
- Malnutrition and cachexia in heart failure. JPEN. 2016; 40(4):475–486. https://doi.org/10.1177/0148607114566854 Crossref, Medline, Google Scholar
- Experience with hydroxychloroquine and azithromycin in the coronavirus disease 2019 pandemic: implications for QT interval monitoring. J Am Heart Assoc. 2020; 9(12):e017144. https://doi.org/10.1161/JAHA.120.017144 Crossref, Medline, Google Scholar
- Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure. Heart Failure Rev. 2020. https://doi.org/10.1007/s10741-020-10016-2 Crossref, Medline, Google Scholar
- Obesity, inflammation, and atherosclerosis. Nature Rev Cardiol. 2009; 6(6):399–409. https://doi.org/10.1038/nrcardio.2009.55 Crossref, Medline, Google Scholar
- Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2018; 8(1):1169. https://doi.org/10.1038/s41598-018-19708-0 Crossref, Medline, Google Scholar
- The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7). Physiol Rev. 2018; 98(1):505–553. https://doi.org/10.1152/physrev.00023.2016 Crossref, Medline, Google Scholar
- Atrial fibrillation and heart failure-results of the CASTLE-AF trial. J Community Hosp Intern Med Perspect. 2018; 8(4):208–210. https://doi.org/10.1080/20009666.2018.1495979 Crossref, Medline, Google Scholar
- Meta-analysis of cardiovascular events and related biomarkers comparing survivors versus non-survivors in patients with COVID-19. Am J Cardiol. 2020. https://doi.org/10.1016/j.amjcard.2020.08.044 Crossref, Medline, Google Scholar
- Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes. Circulat Res. 2017; 120(9):1501–1517. https://doi.org/10.1161/CIRCRESAHA.117.309732 Crossref, Medline, Google Scholar
- COVID-19 and cardiac injury: clinical manifestations, biomarkers, mechanisms, diagnosis, treatment, and follow up. Expert Rev Antiinfective Ther. 2020. https://doi.org/10.1080/14787210.2020.1822737 Crossref, Google Scholar
- Development and validation of a risk score to predict QT interval prolongation in hospitalized patients. Circulation. 2013; 6(4):479–487. https://doi.org/10.1161/CIRCOUTCOMES.113.000152 Medline, Google Scholar
- Predictive analytics for identification of patients at risk for QT interval prolongation: a systematic review. Pharmacother. 2018; 38(8):813–821. https://doi.org/10.1002/phar.2146 Crossref, Medline, Google Scholar
- QT interval prolongation and the risk of torsades de pointes: essentials for clinicians. Curr Med Res Opin. 2013; 29(12):1719–1726. https://doi.org/10.1185/03007995.2013.840568 Crossref, Medline, Google Scholar
- CRP induces NETosis in heart failure patients with or without diabetes. Immunohorizons. 2019; 3(8):378–388. https://doi.org/10.4049/immunohorizons.1900026 Crossref, Medline, Google Scholar
World Health Organization . Coronavirus disease dashboard. 2020. www.covid19.who.int/ (accessed 12 November 2020 ) Google Scholar- Tight junctions in pulmonary epithelia during lung inflammation. Pflugers Arch. 2017; 469(1):135–147. https://doi.org/10.1007/s00424-016-1917-3 Crossref, Medline, Google Scholar
- Elevated D-dimer levels predict adverse outcomes in hospitalised elderly patients with chronic heart failure. Intern Med J. 2019; 49(10):1299–1306. https://doi.org/10.1111/imj.14322 Crossref, Medline, Google Scholar
- Evaluation of variation in D-dimer levels among COVID-19 and bacterial pneumonia: a retrospective analysis. J Thrombosis Thrombolysis, 2020; 50(3):548–557. https://doi.org/10.1007/s11239-020-02171-y Crossref, Medline, Google Scholar
- Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials. BMJ Open. 2018; 8(8):e020545. https://doi.org/10.1136/bmjopen-2017-020545 Crossref, Medline, Google Scholar
- Increased D-dimer levels predict cardiovascular mortality in patients with systolic heart failure. J Thrombosis Thrombolysis. 2012; 33(4):322–328. https://doi.org/10.1007/s11239-011-0635-0 Crossref, Medline, Google Scholar



